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Clin Shoulder Elb > Volume 26(4); 2023 > Article
Momtaz, Ahmad, Singh, Song, Slocum, Ghali, and Abdelfattah: Inpatient or outpatient total elbow arthroplasty: a comparison of patient populations and 30-day surgical outcomes from the American College of Surgeons National Surgical Quality Improvement Program

Abstract

Background

Total elbow arthroplasty (TEA) is uncommon, but growing in incidence. Traditionally an inpatient operation, a growing number are performed outpatient, consistent with general trends in orthopedic surgery. The aim of this study was to compare TEA outcomes between inpatient and outpatient surgical settings. Secondarily, we sought to identify patient characteristics that predict the operative setting.

Methods

Patient data were collected from the American College of Surgeons National Quality Improvement Program. Preoperative variables, including patient demographics and comorbidities, were recorded, and baseline differences were assessed via multivariate regression to predict operative setting. Multivariate regression was also used to compare postoperative complications within 30 days.

Results

A total of 468 patients, 303 inpatient and 165 outpatient procedures, were identified for inclusion. Hypoalbuminemia (odds ratio [OR], 2.5; P=0.029), history of chronic obstructive pulmonary disorder or pneumonia (OR, 2.4; P=0.029), and diabetes mellitus (OR, 2.5; P=0.001) were significantly associated with inpatient TEA, as were greater odds of any complication (OR, 4.1; P<0.001) or adverse discharge (OR, 4.5; P<0.001) and decreased odds of reoperation (OR, 0.4; P=0.037).

Conclusions

Patients undergoing inpatient TEA are generally more comorbid, and inpatient surgery is associated with greater odds of complications and adverse discharge. However, we found higher rates of reoperation in outpatient TEA. Our findings suggest outpatient TEA is safe, although patients with a higher comorbidity burden may require inpatient surgery.

Level of evidence

III

INTRODUCTION

Total elbow arthroplasty (TEA) is a relatively uncommon and complicated surgery. Although it was first designed to treat rheumatoid arthritis of the elbow, indications for TEA have since expanded to include inflammatory arthritis, osteoarthritis, and post-traumatic arthritis, as well as complex, unreconstructable distal humerus fractures [1].While far less common than total knee and hip arthroplasties, the number of TEA procedures performed in the United States continues to increase each year, placing a greater burden on the healthcare system [2].
One method of minimizing this increasing burden is transitioning to an outpatient setting. Studies have documented significant reductions in cost with outpatient total joint arthroplasties [3,4]. Total hip, knee, and shoulder arthroplasties have all proven safe and feasible in this setting [5,6], and projections predict that over half will be outpatient procedures by 2026 [7]. Moreover, recent data on TEA show that outpatient surgery results in decreased costs for patients [8]. While the majority of TEA procedures remain inpatient, from 2010 to 2017, the proportion of TEAs performed outpatient increased from 2.4% to 34.5% [9].
As the proportion of outpatient TEA procedures increases, it is important to monitor the outcomes resulting from this new practice pattern. The aim of this study is twofold: to characterize the patient populations undergoing inpatient and outpatient TEA, respectively, and to compare 30-day outcomes between operative settings. We hypothesize that there will be no apparent differences in these aspects of TEA between inpatient and outpatient settings.

METHODS

This study did not require institutional review board review nor informed consent as ACS NSQIP is a pre-existing, deidentified dataset and is not considered human subjects research.

Data Source and Collection

Data were drawn via a retrospective analysis of the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database. The ACS NSQIP is a multi-institution, multi-center database that collects >270 patient variables from procedures performed at >500 hospitals. Trained clinical reviewers at each site input preoperative, intraoperative, 30-day postoperative, and discharge data based on the patient’s Current Procedural Terminology (CPT) code. This dataset is subject to routine audits for quality assurance. We used CPT codes to identify all adults (patients >18 years of age) who underwent TEA between 2016 and 2020. Patients with incomplete records or with concurrent procedures were excluded.
To isolate the impact of surgical setting, we collected a number of preoperative variables to account for any baseline differences in the two patient populations. We collected the following patient characteristics: demographics, including age, sex, race, and ethnicity; smoking history; American Society of Anesthesiologists class; and common comorbidities such as liver disease, chronic obstructive pulmonary disorder (COPD), diabetes, congestive heart failure, hypertension, and dialysis-dependent kidney disease. Body mass index (BMI) was calculated from patient height and weight.
To assess outcomes, we collected postoperative medical complications within 30 days, including pneumonia, pulmonary embolism, cerebrovascular accidents, deep vein thrombosis, acute renal failure, urinary tract infection, cardiac arrest, and myocardial infarction. We also collected information on both superficial and deep surgical site infections, wound class, blood transfusions, reoperation within 30 days, operation time, hospital length of stay, and discharge disposition. Adverse discharge was defined as patient discharge to any location or facility other than their home.

Statistical Analysis

Patients were stratified based on procedure setting (inpatient or outpatient). Data were analyzed to ensure assumptions were met for statistical analysis. For normally distributed data, independent sample t-tests were performed, while the Wilcoxon rank-sum test was used for non-normally distributed data. Categorical variables were assessed with Fisher’s exact test or chi-square with Kendall tau test. Multiple linear and logistic regression models were also analyzed to ensure criteria were met. Perioperative outcomes with P<0.05 after multivariate regression were considered significant, and results were reported as adjusted odds ratio (OR) and 95% confidence interval (CI).
Statistical analysis was performed with the IBM SPSS ver. 28.0.1.0 (IBM Corp.). Power analysis was conducted with the University of California Los Angeles’ Advanced Research Computing Statistical Methods and Data Analysis G*Power Statistics tool. CIs were set at 95%, with P=0.05 being considered statistically significant.

RESULTS

Demographics

A total of 468 patients, representing 303 inpatient and 165 outpatient procedures, was included in our analysis. In the entire study sample, the average patient age was 67±13 years, with a mean BMI of 29.64±7.18 kg/m2. A total of 379 patients (79.1%) were female, 25 (5.3%) were Black, and 55 (11.8%) were Hispanic. There was no significant difference in mean age (P=0.908) or BMI (P=0.870). The mean length of stay for the inpatient cohort was 3.5 days (standard error [SE], 0.24 days), while the outpatient cohort had a mean length of stay, by definition, of 1 day. The mean operation time was not significantly different at 163 minutes (SE, 3.83 minutes) for the inpatient cohort compared to 160.7 minutes (SE, 5.04 minutes) for the outpatient cohort (P=0.708).

Postoperative Outcomes

After controlling for age, sex, ethnicity, race, and BMI through multivariate regression, we found those undergoing an inpatient procedure to be more likely to have a complication (OR, 4.1; 95% CI, 1.7–9.9; P<0.001) or an adverse discharge disposition (OR, 4.5; 95% CI, 2.2–9.2; P<0.001) but less likely to require reoperation (OR, 0.4; 95% CI, 0.1–0.9; P=0.037) compared to patients undergoing an outpatient procedure. These results can be seen in Figs. 1 and 2.

Preoperative Factors Associated with Inpatient Status

At baseline, those undergoing an inpatient procedure were more comorbid; specifically, we found that patients undergoing an inpatient procedure were more likely to have hypoalbuminemia (OR, 2.5; 95% CI, 1.0–6.2; P=0.029), history of COPD or pneumonia (OR, 2.4; 95% CI, 1.0–5.6; P=0.029), or diabetes (OR, 2.5; 95% CI, 1.4–4.5; P=0.001) relative to patients undergoing outpatient procedures. These results can be seen in Figs. 1 and 2.

DISCUSSION

We found that hypoalbuminemia, a history of COPD or pneumonia, and a diagnosis of diabetes mellitus were more prevalent in the inpatient TEA population. We also found that inpatient TEA is associated with increased odds of both complications within 30 days and adverse discharge but lower odds of reoperation. These data can aid surgeons in selecting both the operative setting and patients by providing a greater understanding of the risks involved.
Increased rates of both complications and adverse discharge in the inpatient population have been reported previously in TEA-specific studies [10] and studies on other total joint operations [5] alike. Our study provides further evidence of this trend. Furthermore, we identified specific patient characteristics and comorbidities that significantly increased the odds of an inpatient TEA procedure, which, to our knowledge, has not been done previously.
While Furman et al. [10] found no difference in TEA reoperation rates, increased reoperation rates in outpatient total joint arthroplasty have been reported [11]. Arshi et al. [12] obtained similar findings for shoulder arthroplasties—that is, reoperation rates are higher following outpatient procedures, typically due to postoperative infections. Although outpatient surgery is typically associated with significant savings, the increased rate of reoperations could make it a less cost-effective option [8,13]. Better patient selection, guided by studies such as our own, may also minimize the disparity in reoperation rates.
While Arshi et al. [12] found that reoperation due to surgical site infection was more common in the outpatient population, other studies suggest that infection rates are not significantly different between surgical settings [14]. TEA-specific studies have reported relatively high reoperation rates (up to 41%), often attributed to complications such as component loosening and periprosthetic fracture [15-17]. However, in these studies, the average time to reoperation ranged from 1.8 to >7 years. As our analysis was restricted to 30 days postoperatively, our results suggest that this discrepancy in reoperation rates is due to acute complications, such as wound infection. Therefore, better infection control may mitigate these observed differences. However, further research comparing longitudinal reoperation rates is warranted.
With respect to complications, generally, outpatient TEA has proven to be safe and produce reliable outcomes; however, we recorded significantly more complications resulting from inpatient surgery. Several studies found no difference in inpatient and outpatient complication rates; however, those studies had limitations [10,18,19]. Stone et al. [18], although they tracked complications out to 90 days, enrolled only 28 patients. The study by Albert et al. [19] was restricted to procedures performed by a single surgeon with changing practice patterns over the 18 years of perioperative data included in the study, limiting the generalizability of its findings. However, Furman et al. [10] reported results consistent with our own: greater surgical and medical complications in the inpatient setting. However, while their study had a sample size comparable to our own and a robust statistical analysis, our study drew data from more recent years; therefore, these differences are likely the result of changes over time.
We also found that the inpatient cohort had a significantly greater comorbidity burden. Specifically, our results indicate that hypoalbuminemia, COPD or pneumonia, and diabetes mellitus are associated with increased odds of an inpatient TEA procedure. Hypoalbuminemia, a sign of malnutrition, has been found to predict postoperative complications, longer hospital stays, and mortality after hip fracture repair [20]. It is also associated with postoperative complications and mortality after outpatient surgery [21]. In a related study on total shoulder arthroplasty, Mehta et al. [22] found that patients undergoing outpatient procedures were less likely to have hypoalbuminemia, further supporting this association. COPD is also associated with postoperative complications after both total hip and knee arthroplasty [23,24]; specifically, COPD patients were at increased odds of developing pneumonia, undergoing unplanned intubation, and requiring ventilator support for >48 hours within 30 days of the arthroplasty procedure.
With respect to diabetes mellitus, Jämsen et al. [25] found hemoglobin A1c (HbA1c) concentration to be an accurate predictor of perioperative hyperglycemia; nearly all patients with an HbA1c concentration ≥6.5% (a level indicating diabetes) in their study experienced hyperglycemia after hip and knee arthroplasty. Post-arthroplasty hyperglycemia is associated with increased wound complications and mortality [26]. Brophy et al. [27] found that diabetes was associated with postoperative infection in the outpatient setting; our findings indicate that surgeons are more likely to opt for an inpatient procedure with these patients. While A1c and blood sugar are important considerations when selecting candidates for outpatient surgery, proper glycemic control in diabetic patients can bring postoperative complication rates in line with those among patients without diabetes [28].
All of these characteristics are associated with increased complications and mortality after total knee and hip arthroplasty. Hypoalbuminemia, history of COPD, and uncontrolled diabetes are all considered possible exclusion criteria for outpatient total hip and knee arthroplasty [29]. Our results show that surgeons are also wisely electing to perform TEA in a setting where these patients can benefit from close postoperative monitoring. This represents the existence of a significant patient population that is limited in its access to outpatient total joint arthroplasty due to the inherent risk of complications. Future research into pre- and post-arthroplasty risk mitigation for patients with these characteristics would improve patient safety and eventually open the door for cost-saving outpatient arthroplasty.
Our findings of greater comorbidity burden in the inpatient population are consistent with findings by Guareschi et al. [30], who found that patients undergoing inpatient shoulder arthroplasty had higher American Society of Anesthesiologists class scores relative to those undergoing outpatient procedures. These higher-risk patients with more comorbidities tend to require the more intense postoperative care offered in an inpatient setting. However, our results suggest that optimizing pre-operational patient nutrition status, identifying pulmonary function parameters that predict postoperative complications, and ensuring proper glycemic control could expand eligibility for outpatient TEA, allowing a subgroup of this traditionally inpatient population to potentially transition safely to outpatient arthroplasty.
Our study benefits from including a far larger sample size than most other extant studies. The ACS NSQIP provides cross-country sampling, allowing us to draw conclusions that should be generalizable across the United States. Additionally, we had access to numerous patient variables and demographic information, allowing us to control for key factors (common comorbidities, age, race, and BMI) that can influence outcomes. These data are important for surgeons to appropriately select candidates for outpatient surgery.
As with any study, ours has several limitations. First, this was a retrospective study, not a randomized controlled trial. Second, the ACS NSQIP, while it allows for an exceptionally large sample size representative of the country, lacks several key variables, such as patient-reported outcomes, functional outcomes, long-term outcomes, and complications beyond 30 days. We also lacked information on variables and complications specific to TEA procedures, such as aseptic loosening, ulnar neuropathy, or the different forms of prosthesis wear and failure, and were unable to account for important patient characteristics like insurance and socioeconomic status, which may have significant impacts on outcomes. Further research on these orthopedic-specific outcomes and complications is warranted.

CONCLUSIONS

Hypoalbuminemia, COPD or pneumonia, and diabetes mellitus are significantly more prevalent in the inpatient TEA population. These patients are more comorbid and warrant the increased level of care offered with inpatient surgery. Notably, while inpatient TEA is associated with greater odds of complications and adverse discharge, it lowers the odds of reoperation. Our findings suggest that outpatient TEA is generally safe and a viable option; however, patients with a greater comorbidity burden are preferentially treated in the inpatient setting. Further research is warranted to optimize patient selection in the outpatient setting and potentially to realize significant cost savings.

NOTES

Author contributions

Conceptualization: FA, AG, AA. Data curation: DM. Formal analysis: DM. Investigation: FA, AS, ES, DS, AA. Methodology: DM. Project administration: AS, ES, AG. Supervision: AA. Visualization: DM, ES. Writing – original draft: FA, AS, ES, DS, AG. Writing – review & editing: DM, FA, AS, ES, DS, AG, AA.

Conflict of interest

None.

Funding

None.

Data availability

Contact the corresponding author for data availability.

Acknowledgments

None.

Fig. 1.
Forest plot, odds ratios (ORs), and 95% confidence intervals (CIs) of selected outcomes or preoperative patient characteristics in the inpatient total elbow arthroplasty population. COPD: chronic obstructive pulmonary disorder.
cise-2023-00486f1.jpg
Fig. 2.
(A, B) Bar graph representing comparative risk of selected outcomes or odds of diagnosed comorbidity in the inpatient versus outpatient TEA total elbow arthroplasty populations. COPD: chronic obstructive pulmonary disorder.
cise-2023-00486f2.jpg

REFERENCES

1. Zhang D, Chen N. Total elbow arthroplasty. J Hand Surg Am 2019;44:487–95.
crossref pmid
2. Zhou H, Orvets ND, Merlin G, et al. Total elbow arthroplasty in the United States: evaluation of cost, patient demographics, and complication rates. Orthop Rev (Pavia) 2016;8:6113.
pmid pmc
3. Gibon E, Parvataneni HK, Prieto HA, Photos LL, Stone WZ, Gray CF. Outpatient total knee arthroplasty: is it economically feasible in the hospital setting. Arthroplast Today 2020;6:231–5.
crossref pmid pmc
4. Gregory JM, Wetzig AM, Wayne CD, Bailey L, Warth RJ. Quantification of patient-level costs in outpatient total shoulder arthroplasty. J Shoulder Elbow Surg 2019;28:1066–73.
crossref pmid
5. Erickson BJ, Shishani Y, Jones S, et al. Outpatient vs. inpatient reverse total shoulder arthroplasty: outcomes and complications. J Shoulder Elbow Surg 2020;29:1115–20.
crossref pmid
6. Shah RR, Cipparrone NE, Gordon AC, Raab DJ, Bresch JR, Shah NA. Is it safe? Outpatient total joint arthroplasty with discharge to home at a freestanding ambulatory surgical center. Arthroplast Today 2018;4:484–7.
crossref pmid pmc
7. DeCook CA. Outpatient joint arthroplasty: transitioning to the ambulatory surgery center. J Arthroplasty 2019;34:S48–50.
crossref pmid
8. Baxter NB, Davis ES, Chen JS, Lawton JN, Chung KC. Utilization, complications, and costs of inpatient versus outpatient total elbow arthroplasty. Hand (N Y) 2023;18:509–15.
crossref pmid
9. Pasternack JB, Mahmood B, Martins AS, Choueka J. The transition of total elbow arthroplasty into the outpatient theater. JSES Int 2020;4:44–8.
crossref pmid
10. Furman AA, Sherman AE, Plantz MA, Marra G, Saltzman MD. Differences in 30-day outcomes between inpatient and outpatient total elbow arthroplasty (TEA). J Shoulder Elbow Surg 2020;29:2640–5.
crossref pmid
11. Basques BA, Tetreault MW, Della Valle CJ. Same-day discharge compared with inpatient hospitalization following hip and knee arthroplasty. J Bone Joint Surg Am 2017;99:1969–77.
crossref pmid
12. Arshi A, Leong NL, Wang C, et al. Relative complications and trends of outpatient total shoulder arthroplasty. Orthopedics 2018;41:e400–9.
crossref pmid
13. Lovald ST, Ong KL, Malkani AL, et al. Complications, mortality, and costs for outpatient and short-stay total knee arthroplasty patients in comparison to standard-stay patients. J Arthroplasty 2014;29:510–5.
crossref pmid
14. Lands H, Harm R, Hill M, Patel K, Spanyer J. Outpatient total hip and knee arthroplasty exhibit similar early complication rates to inpatient procedures. J Orthop 2021;27:69–73.
crossref pmid pmc
15. Perretta D, van Leeuwen WF, Dyer G, Ring D, Chen N. Risk factors for reoperation after total elbow arthroplasty. J Shoulder Elbow Surg 2017;26:824–9.
crossref pmid
16. Park JG, Cho NS, Song JH, Lee DS, Rhee YG. Clinical outcomes of semiconstrained total elbow arthroplasty in patients who were forty years of age or younger. J Bone Joint Surg Am 2015;97:1781–91.
crossref pmid
17. Celli A, Morrey BF. Total elbow arthroplasty in patients forty years of age or less. J Bone Joint Surg Am 2009;91:1414–8.
crossref pmid
18. Stone MA, Singh P, Rosario SL, Omid R. Outpatient total elbow arthroplasty: 90-day outcomes. J Shoulder Elbow Surg 2018;27:1311–6.
crossref pmid
19. Albert BM, Lee A, McLendon TW, Devereaux RS, Odum CC, Foulkes GD. Is total elbow arthroplasty safe as an outpatient procedure. J Surg Orthop Adv 2017;26:25–8.
pmid
20. Aldebeyan S, Nooh A, Aoude A, Weber MH, Harvey EJ. Hypoalbuminaemia: a marker of malnutrition and predictor of postoperative complications and mortality after hip fractures. Injury 2017;48:436–40.
crossref pmid
21. Curran S, Apruzzese P, Kendall MC, De Oliveira G. The impact of hypoalbuminemia on postoperative outcomes after outpatient surgery: a national analysis of the NSQIP database. Can J Anaesth 2022;69:1099–106.
pmid
22. Mehta N, Bohl DD, Cohn MR, et al. Trends in outpatient versus inpatient total shoulder arthroplasty over time. JSES Int 2022;6:7–14.
crossref pmid
23. Yakubek GA, Curtis GL, Sodhi N, et al. Chronic obstructive pulmonary disease is associated with short-term complications following total hip arthroplasty. J Arthroplasty 2018;33:1926–9.
crossref pmid
24. Yakubek GA, Curtis GL, Khlopas A, et al. Chronic obstructive pulmonary disease is associated with short-term complications following total knee arthroplasty. J Arthroplasty 2018;33:2623–6.
crossref pmid
25. Jämsen E, Nevalainen PI, Eskelinen A, Kalliovalkama J, Moilanen T. Risk factors for perioperative hyperglycemia in primary hip and knee replacements. Acta Orthop 2015;86:175–82.
crossref pmid pmc
26. Stryker LS, Abdel MP, Morrey ME, Morrow MM, Kor DJ, Morrey BF. Elevated postoperative blood glucose and preoperative hemoglobin A1C are associated with increased wound complications following total joint arthroplasty. J Bone Joint Surg Am 2013;95:808–S2.
crossref pmid
27. Brophy RH, Bansal A, Rogalski BL, et al. Risk factors for surgical site infections after orthopaedic surgery in the ambulatory surgical center setting. J Am Acad Orthop Surg 2019;27:e928–34.
crossref pmid
28. Wukich DK. Diabetes and its negative impact on outcomes in orthopaedic surgery. World J Orthop 2015;6:331–9.
crossref pmid pmc
29. Ardon AE. Safety considerations for outpatient arthroplasty. Clin Sports Med 2022;41:281–9.
crossref pmid
30. Guareschi AS, Eichinger JK, Friedman RJ. Patient outcomes after revision total shoulder arthroplasty in an inpatient vs. outpatient setting. J Shoulder Elbow Surg 2023;32:82–8.
crossref pmid
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