Clinical results of conservative management in patients with full-thickness rotator cuff tear: a meta-analysis

Masaki Karasuyama; Masafumi Gotoh; Keiji Tahara; Junichi Kawakami; Kazuya Madokoro; Takashi Nagamatsu; Takaki Imai; Nobuya Harada; Yu Kudo; Naoto Shiba

doi:10.5397/cise.2020.00031

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Karasuyama, Gotoh, Tahara, Kawakami, Madokoro, Nagamatsu, Imai, Harada, Kudo, and Shiba: Clinical results of conservative management in patients with full-thickness rotator cuff tear: a meta-analysis

Original Article

Clinics in Shoulder and Elbow 2020; 23(2): 86-93.

Published online: May 7, 2020

DOI: https://doi.org/10.5397/cise.2020.00031

Clinical results of conservative management in patients with full-thickness rotator cuff tear: a meta-analysis

Masaki Karasuyama¹

, Masafumi Gotoh², Keiji Tahara³, Junichi Kawakami^1,⁴, Kazuya Madokoro⁵, Takashi Nagamatsu⁴, Takaki Imai⁶, Nobuya Harada⁴, Yu Kudo⁴, Naoto Shiba⁷

¹Department of Physical Therapy, Kyushu Nutrition Welfare University, Kitakyushu, Japan

²Department of Orthopedic Surgery, Kurume University Medical Center, Kurume, Japan

³Department of Orthopedic Surgery, Tahara Orthopedic Clinic, Kitakyushu, Japan

⁴Kurume University School of Medicine Graduate School, Kurume, Japan

⁵Department of Physical Therapy, Technical School of Medical and Welfare Ryokuseikan, Tosu, Japan

⁶Department of Rehabilitation, Keishinkai Hospital, Tosu, Japan

⁷Department of Orthopedic Surgery, Kurume University, Kurume, Japan

Correspondence to: Masaki Karasuyama Department of Physical Therapy, Kyushu Nutrition Welfare University, 1-5-1 Kuzuhara Takamatsu, Kitakyushu, Fukuoka, 800-0298 Japan
Tel: +81-93-471-7912, Fax: +81-93-473-4161, Email: arukanjero@yahoo.co.jp

Received: January 25, 2020 Revised: March 21, 2020 Accepted: March 24, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Several systematic reviews have reported on the conservative treatment of full-thickness rotator cuff tears; however, clinical results of this treatment still remain determined.

Methods

PubMed, Cochrane Library, PEDro, and CINAHL databases were systematically searched for randomized clinical trials and observational studies. Two independent researchers reviewed a total of 2,981 articles, 28 of which met the criteria for inclusion in the study. Clinical outcome measures included Constant score, visual analog scale score for pain, range of motion, and short-form 36 questionnaires. The meta-analysis used a linear mixed model weighted with the variance of the estimate.

Results

The meta-analysis showed a significant improvement after surgery. Pain score is 26.2 mm (1 month) to 26.4 mm (3 months), and 24.8 mm (12 months) (P<0.05); active abduction: 153.2º (2 months), 159.0º (6 months), 168.1º (12 months) (P<0.05); Constant score: 67.8 points (2 months) to 77.2 points (12 months) (P<0.05); short-form 36 questionnaires “vitality” section: 57.0 points (6 months) to 70.0 points (12 months) (P<0.05).

Conclusions

Our data confirmed the effectiveness of conservative treatment in patients with full-thickness rotator cuff tears 12 months post-intervention. The results suggest that conservative treatment for patients with full-thickness rotator cuff tears should be the first line of treatment before considering surgery.

Key Words: Shoulder; Rotator cuff injuries; Conservative management

INTRODUCTION

Rotator cuff tear is a common condition in middle-aged and elderly patients. Yamamoto et al. [1] investigated the prevalence of rotator cuff tear in 683 patients and reported that 20%–50% of individuals aged >60 years had such an injury. Moreover, Yamaguchi et al. [2] investigated 588 patients and found that 376 (63.9%) had rotator cuff tear. Symptoms of rotator cuff tear include pain, weakness, and limitation of motion. In these patients, conservative treatment is primarily chosen and includes nonsteroidal anti-inflammatory drug administration, steroid injection, hyaluronic acid injection, physical therapy, and exercise therapy. Previous studies reported acceptable results in patients with rotator cuff tear treated with combinations of rehabilitation and local corticosteroid injections [3].

　Systematic reviews on the conservative treatment of full-thickness rotator cuff tear (FT-RCT) have been reported [4]; however, previous reports have not provided sufficient knowledge on conservative treatment due to a paucity of high-quality studies. These results prompted us to conduct a systematic review of the conservative treatment of FT-RCT, including observational studies. Therefore, the purpose of the present study was to perform meta-analysis of clinical outcomes of patients with FT-RCT who received conservative treatment.

METHODS

We systematically searched the PubMed, Cochrane Library, PEDro, and CINAHL databases for studies conducted between January 1992 and July 2017, with the search terms rotator cuff, rotator cuff tear, subacromial impingement syndrome, rehabilitation, physiotherapy, physical therapy, exercise, conservative, and nonoperative. The references of the selected studies were also reviewed, when applicable, to identify additional studies. The inclusion criteria were as follows: randomized clinical trial; observational study; study investigating full thickness, massive, or inoperable rotator cuff tear; study explicitly mentioning that the treatment group received conservative treatment for this condition; and study reporting one or more of the outcome measures.

　A meta-analysis was performed to estimate the clinical outcomes of conservative treatment in patients with FT-RCT. Case reports were excluded from the analysis. For each included article, synthesis began by pooling all reported outcomes gathered at all reported time points. The mean and standard deviation of the continuous results (i.e., Constant score and pain) were extracted from each study according to the follow-up period. When means or standard deviations were not reported in an article, they were calculated using the available information, if possible. Outcomes reported by two or more studies were pooled in a meta-analysis. Constant score, pain (visual analog scale [VAS]), range of motion (ROM) (active flexion/active abduction), and short-form 36 questionnaires (SF-36) results were the selected outcomes measured because they were reported as the mean and standard deviation of effect indicators in the included studies. The reasons for the outcomes that could not be analyzed were as follows: only one article was used as an effect indicator; articles used as effect indicators with unknown average or standard deviations, and a differing measurement method from other articles.

　Analysis was performed using JMP ver. 13 (SAS Institute Inc., Cary, NC, USA). The meta-analysis used a linear mixed model [5]weighted with the variance of the estimate. A P-value less than 0.05 was considered statistically significant.

RESULTS

Study Selection

The initial database search yielded 2,981 abstracts. After removal of duplicates, 2,881 articles remained for review, of which 28 met the criteria for inclusion in the study. Of all included studies, six were randomized clinical trials, four were cohort studies, 15 were case series, and three were case reports (Fig. 1).

Characteristics of Studies

A total of 1,824 patients was included in the 28 investigations reviewed. The average age of patients who participated in these investigations was 62.9 years (44–83 years). The intervention period of the conservative treatment in these investigations ranged from 3 weeks to 2 years. The mean final outcome measurements were performed at a minimum of 2 months to a maximum of 7.6 years (Table 1) [3,6-32].

　The outcome measures used in studies were ROM (15 trials) [6,8,11-14,16,18-20,24-26,31,32], Constant score (13 trials) [3,9-11,14,16,18-22,24,30], pain (10 trials) [3,6,8-10,12,16,18,19,22], strength (10 trials) [7,8,13,14,16,19-21,25,32], American Shoulder and Elbow Surgeons score (seven trials) [7,15,19,20,29-31], SF-36 score (four trials) [19,20,23,27], Western Ontario Rotator Cuff Index (three trials) [7,8,15], Simple Shoulder Test score (three trials) [9,14,27], University of California at Los Angeles Shoulder Score (two trials) [26,31], Japanese Orthopedic Association Score (two trials) [17,28], satisfaction (two trial) [19,26], shoulder rating questionnaire (one trial) [25], disability (one trial) [9], impairment (one trial) [22], Modified Wolfgang’s Criteria (one trial) [32], Disabilities of the Arm, Shoulder, and Hand score (one trial) [7], Quick Disabilities of the Arm, Shoulder, and Hand score (one trial) [6], Oxford Shoulder Disability Questionnaire score (one trial) [23], SF-12 score (one trial) [15], Single Assessment Numeric Evaluation score (one trial) [15], shoulder activity scale score (one trial) [15], night pain (one trial) [18], EuroQol questionnaire score (one trial) [16], Rotator Cuff Quality of Life Index (one trial) [13], Global Rating of Change (one trial) [6], Dutch Simple Shoulder Test score (one trial) [9], and shoulder functional status (one trial) [3].

Meta-Analysis

The analysis showed change in constant score, pain (VAS), ROM (active flexion/active abduction), and SF-36 1 year after the intervention from baseline. For the constant score, six studies [9,16,19,20,22,24] involving 174 shoulders were analyzed. The Constant score was 54.3 points (baseline), 67.8 points (2 months), 73.1 points (3 months), 78.0 points (6 months), and 77.2 points (12 months), and trajectories over time showed a significant difference (P<0.05). Constant score at 2–12 months after intervention was significantly higher than that at baseline (P<0.05) (Fig. 2A).

　For the pain variable (VAS), six studies [3,8,9,16,19,22] involving 209 shoulders were included. The change in pain (VAS) was from 59.8 mm (baseline) to 26.2 mm (1 month), 35.1 mm (2 months), 26.4 mm (3 months), 30.4 mm (6 months), and 24.8 mm (12 months), and trajectories over time showed a significant difference (P<0.05). Pain (VAS) at 1–12 months after intervention was significantly lower than that at baseline (P<0.05) (Fig. 2B).

　For the ROM, five studies [8,16,19,20,24] involving 144 shoulders were included. The ROM (active flexion/active abduction) changed from 135.7º/122.5º (baseline) to 159.5º/153.2º (2 months), 161.7º/156.4º (3 months), 160.0º/159.0º (6 months), and 171.9º/168.1º (12 months) (Fig. 2C). The transition of active flexion trajectories over time showed no significant difference, but active abduction showed a significant difference (P<0.05). Active abduction at 2, 6, and 12 months after intervention was significantly higher than that at baseline (P<0.05).

　For the SF-36, two studies [19,20] involving 71 shoulders were included. In SF-36, the mean value of "vitality" showed a significant improvement at 6 and 12 months after intervention (all P<0.05). There was no significant difference in the other seven subscales because of missing data; however, the mean values of these scales tended to improve at 6 months after intervention (Fig. 3).

DISCUSSION

Several systematic reviews have reported conservative treatment approaches for FT-RCT. Seida et al. [33] reported a systematic review of conservative and surgical treatments. The review indicated limited data needed to reach clear conclusions for most of the interventions investigated. Recently, Piper et al. [34] used meta-analysis to compare conservative and surgical treatments of FT-RCTs. They reported a statistically significant improvement in clinical outcomes of surgical treatment compared to conservative treatment for patients with rotator cuff tear. However, clinical results from conservative treatment are limited. Therefore, the present meta-analysis focused on the effectiveness of conservative management in patients with FT-RCT by including randomized trials and observational studies. Our data showed that, in patients with FT-RCT who underwent conservative management, pain (VAS), ROM (active flexion/abduction), and Constant score improved at 3 months after treatment and SF-36 improved at 6 months after treatment.

　In this meta-analysis, we found that treatment response in terms of Constant score followed a pattern of rapid improvement in the first 2 months after intervention and then recovery plateaus. Baydar et al. [20] showed that the Constant score significantly improved 6 months after conservative treatment in patients with FT-RCT. Moosmayer et al. [19] compared patient outcomes after surgical or conservative treatment of FT-RCTs. Based on their results, 1 year after treatment, there was an improvement in the mean Constant score in both groups. The results of these studies suggest that conservative treatment produces satisfactory outcomes in the short and medium term. In this study, the Constant score significantly improved 2 months after treatment. Therefore, these results suggest that conservative treatment leads to significant improvement in functional outcomes in the first 2 months after therapy, after which the recovery plateaus.

　 Moosmayer et al. [19] showed that the pain score improved at 1 year follow-up in patients with FT-RCT who received conservative treatment. Similarly, Koubâa et al. [22] reported that patients with FT-RCT who received conservative treatment had improved pain scores. We showed that patients with FT-RCT demonstrated improved pain with conservative management. Altogether, the results of this review suggest the significance of improved pain within 2 months.

　Several studies have reported that short-term and medium-term conservative treatment has a positive effect on ROM in patients with FT-RCT. Baumer et al. [8] reported that ROM in 25 patients with FT-RCT significantly improved 2 months after conservative treatment. Baydar et al. [20] and Moosmayer et al. [19] reported that ROM significantly improved 6 months after conservative treatment. In the present study, ROM significantly improved 2, 6, and 12 months after treatment. Thus, these results are consistent with previous studies on the importance of conservative treatment to improve ROM in patients with FT-RCT.

　The SF-36 was developed in 1997, and consisted of eight independent items of general health, physical functioning, role physical, bodily pain, vitality, social functioning, role emotional, and mental health. The SF-36 scale has been widely used to evaluate patient quality of life, including both physical and mental health. The scales and summary components ranged from 0 to 100, of which higher values denote better functioning and fewer limitations. The present study evaluated this patient-based assessment score in patients with FT-RCT who underwent conservative treatment. As a result, "vitality," which was related to mental health, significantly improved at 6 and 12 months after treatment. Due to the lack of data, we were unable to analyze the other factors, but we indicated the effectiveness of conservative treatment in terms of the patient-based scale.

　There were several limitations in this study. First, various types of FT-RCT were included (e.g., isolated supraspinatus tear and two or three tendon tears). Second, there was a lack of uniformity in the treatment modalities among the studies evaluated. Third, this study did not perform a subgroup analysis of patients with FT-RCT whose conservative treatment failed. Fourth, the parameters that indicated positive results of conservative treatment were limited. Therefore, future studies are warranted to address these issues.

　This study showed that, for patients with FT-RCT who underwent conservative management, pain, ROM, and Constant score improved at 3 months after treatment and SF-36 improved at 6 months after treatment. Our data confirmed the effectiveness of conservative treatment in patients with FT-RCT within 12 months postintervention.

　Our data confirmed acceptable results for conservative treatment in patients with FT-RCTs. Pain, ROM (active abduction), and Constant score improved 3 months after treatment, and the “vitality” score of the SF-36 improved 6 months after treatment. We also confirmed that these effects continued for 1 year after treatment. Therefore, these results suggest that conservative treatment for patients with FT-RCTs should be the first step before considering surgery.

NOTES

Financial support

None.

Conflict of interest

None.

Fig. 1.

Flowchart of the articles included in the systematic review.

Fig. 2.

Plot showing the Constant score (A), pain (B), and active flexion/active abduction (C) for the conservative management group. Whiskers indicate 95% confidence interval. *P<0.05.

Fig. 3.

Graph showing the short-form 36 questionnaires (SF-36)score for the conservative management group. *P<0.05.

Table 1.

Characteristics of the included studies

Study	Type of study	Subject (n)	Sample size	Mean age (yr)	Sex (M:F)	Outcome measure	Follow-up
Mischke et al. (2016) [6]	Case report	Nonoperative (1)	1	57	F, 1	Pain (VAS), quick	Visit, 13
						DASH, GROC, ROM
Miller et al. (2016) [7]	Case series	Nonoperative (5)	5	60.2	2:3	ASES, WORC, DASH, strength	3 mo
Baumer et al. (2016) [8]	Cohort study	Physical therapy (25)	25	60.2	7:18	Pain (VAS), WORC, strength, ROM	8 wk
		Healthy controls (25)	25	59	7:18
Lambers Heerspink et al. (2015) [9]	RCT	Conservative (31)	31	60.5	20:11	Pain (VAS), disability (VAS), CS, DSST	1 yr
		Surgery (25)	25	60.8	15:10
Kukkonen et al. (2015) [10]	RCT	Physiotherapy (55)	55	64	24:31	CS, pain (VAS)	2 yr
		Acromioplasty and physiotherapy (57)	57	65	29:28
		Repair, acromioplasty, and physiotherapy (55)	55	65	29:26
Collin et al. (2015) [11]	Case series	Nonoperative (45)	45	67	17:28	ROM, CS	2 yr
Nejati et al. (2014) [12]	Case report	Nonoperative (1)	1	53	M, 1	Pain (VAS), ROM	6 mo
Boorman et al. (2014) [13]	Case series	3-Month supervised program of nonoperative	93	60	54:39	RC-QOL, ROM, strength	3 mo
		“Successful (no surgery)” (70)
		“Failed (underwent surgery)” (23)
Benazzo et al. (2014) [14]	Case report	Nonoperative (1)	1	23	F, 1	SST, CS, ROM, strength	29 mo
Kuhn et al. (2013) [15]	Cohort study	Physiotherapy (422)	422	62.6	206:194	SF-12, ASES, WORC, SANE, Shoulder Activity Scale	2 yr
Krischak et al.(2013) [16]	RCT	Occupational therapy (22)	38	55.3	24:14	Pain (VAS), EQ-5D, strength, ROM, CS	2 mo
		Home-based exercises (16)
Kijima et al. (2012) [17]	Case series	Nonoperative (43)	43	62	30:13	JOAS	12 yr
Gialanella et al. (2011) [3]	RCT	Physiotherapy＋corticosteroids (×1) (20)	60	78.7	2:18	Pain (VAS), shoulder functional status, CS	6 mo
		Physiotherapy＋corticosteroids (×2) (20)		77.3	1:19
		Physiotherapy (20)		79.4	2:18
Tanaka et al. (2010) [18]	Case series	Conservative (128)	128	69	67:61	CS, night pain, ROM	3.7 mo
Moosmayer et al. (2010) [19]	RCT	Nonoperative (51)	51	61	36:15	CS, ASES, SF-36, pain (VAS), ROM, strength, satisfaction	1 yr
		Operative (52)	52	59	37:15
Baydar et al. (2009) [20]	Case series	Nonoperative (20)	20	60.9	7:13	ROM, ASES, CS, SF-36, strength	6 mo
Levy et al. (2008) [21]	Case series	Nonoperative (17)	17	80	6:11	Strength, CS	9 mo
Koubâa et al. (2006) [22]	Case series	Conservative (24)	24	59.2	9:15	CS, pain (VAS), impairment	6 mo
Ainsworth (2006) [23]	Case series	Nonoperative (10)	10	76	4:6	OSDQ, SF-36	3 mo
Heers et al. (2005) [24]	Case series	Nonoperative (34)	34	60.4	13:23	CS, ROM	3 mo
Vad et al. (2002) [25]	Cohort study	G1a: physiotherapy+medication (28)	108	G1:63.2	50:58	SRQ, ROM, strength	3.2 yr
		G1b: physiotherapy+medication+steroid (12)		G2:62.9
		G2: arthroscopic (failed G1a/1b) (32)		G3:59.4
		G3: primary surgical repair (36)
Shibata et al. (2001) [26]	RCT	G1: sodium hyaluronate (38)	78	G1:59.5	55:23	UCLA, ROM, satisfaction	24 wk
		G2: Steroid (40)		G2:60.4
Goldberg et al. (2001) [27]	Case series	Nonoperative (46)	46	65	22:24	SST, SF-36	2.5 yr
Yamada et al. (2000) [28]	Case series	Nonoperative (14)	14	70	9:5	JOAS	4 yr
		Operative (26)	26	62	24:2
Wirth et al. (1997) [29]	Case series	Nonoperative (60)	60	64	38:22	ASES	2 yr
Hawkins et al. (1995) [30]	Case series	Nonoperative (33)	33	59.6	27:6	CS, ASES	3.8 yr (2.6–4.6)
Bokor et al. (1993) [31]	Case series	Nonoperative (53)	53	62.2	40:13	ASES, UCLA, ROM	7.6 yr
							(3.7–12)
Itoi et al. (1992) [32]	Case series	Nonoperative (124)	124	63	59:55	MWC, ROM, strength	3.4 yr (1–9)

VAS, visual analog scale; DASH, Disabilities of the Arm, Shoulder, and Hand; GROC, global rating of change; ROM, range of motion; ASES, American Shoulder and Elbow Surgeons; WORC, Western Ontario Rotator Cuff index; RCT, randomized controlled trial; CS, Constant score; DSST, Dutch Simple Shoulder Test; RC-QOL, Rotator Cuff Quality-of-Life Index; SST, Simple Shoulder Test; SF-12, short-form 12 questionnaires; SANE, Single Assessment Numeric Evaluation; EQ-5D, EuroQol questionnaire; JOAS, Japanese orthopedic association score; SF-36, G, group; short form 36 questionnaires; OSDQ, Oxford Shoulder Disability Questionnaire; SRQ, shoulder rating questionnaire; UCLA, University of California at Los Angeles Shoulder Score; MWC, modified Wolfgang’s criteria.

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